Two people are in serious condition and a further two are in moderate condition after a crash on State Highway 83.
Police said the crash has closed the Omarama-Otematata Road on the road, near the intersection of Prohibition Road.
Emergency services were called at 12.35pm, after two vehicles collided. Police added one of these vehicles was towing a caravan.
“The serious crash unit has been advised.”
Traffic management is being arranged, however, motorists should expect delays and postpone travel if possible.